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El test de Ames se realizó con E2, NET, EN-NET y AC-NET; NET se investigó adicionalmente con el test UDS.

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The high risk group, while numerically smaller, is made up of patients receiving bisphosphonates for the management of malignancy affecting the skeleton, both primary and secondary.

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Primary end points were new vertebral fracture (in patients not taking concomitant osteoporosis medications) and hip fracture (in all patients).

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To investigate whether the administration of bisphosphonate (Aclasta) would suppress bone lesions after adoptive transfer of MuTuDCs subcutaneously on the calvaria, mice were treated with a single dose of PBS or Aclasta one week after MuTuDC injection.

Pharmacokinetics not affected by renal impairment; dosage adjustment not necessary.

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