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DBP of 5 mm Hg is associated with reductions of at least 21% in the incidence of coronary heart disease and at least 34% in the incidence of stroke.

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Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks.

Losartan potassium may be administered with other antihypertensive agents.

Losartan potassium tablets can be administered once or twice daily with total daily doses ranging from 25 mg to 100 mg.

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Although calcium channel blockers, nitrates, and angiotensin-converting enzyme (ACE) inhibitors are frequently used to treat diastolic dysfunction, there have been no large prospective trials proving either acute or long-term efficacy.

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The risk of a doubling of the serum creatinine concentration was also reduced by 25 percent with losartan.

Hydrochlorothiazide Combination Therapy with Irbesartan Monotherapy in the Treatment of Moderate or Severe Hypertension in Diabetic and Obese Hypertensive Patients: A Post-Hoc Analysis Review.

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In the Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan (RENAAL) study involving 1513 patients treated with losartan potassium or placebo, the overall incidences of reported adverse events were similar for the two groups.

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Aldosterone causes the of the kidneys to increase the reabsorption of from the tubular fluid back into the blood, while at the same time causing them to excrete ions into the tubular fluid which will become urine.

After a 3-month, open-label, run-in period during which patients received 100 mg of losartan daily, patients were randomly assigned to receive 6 months of treatment with aliskiren (150 mg daily for 3 months, followed by an increase in dosage to 300 mg daily for another 3 months) or placebo, in addition to losartan.

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The blood-pressure measurements for the three groups are shown in Figure 1 Average Systolic, Mean Arterial, and Diastolic Blood Pressures at Randomization (0 Months) and during Follow-up, According to Treatment Group.

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For further blood pressure reduction other antihypertensives should be added (see CLINICAL PHARMACOLOGY, Pharmacodynamics and Clinical Effects, Losartan Potassium, Reduction in the risk of stroke).

Although they belong to the same class of drugs, losartan and candesartan have important pharmacological differences.

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Losartan belongs to a group of medicines known as angiotensin-II receptor antagonists.

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Five patients (three in group 2 and two in group 4) withdrew during uptitration because of adverse events.

Two systems of nomenclature are used in reference to angiotensin-II receptor antagonists: one system employs Roman numerals, and the other is based on the amino acids that make up the A-I and A-II receptors (AT 1 receptor and AT 2 receptor).

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Inhibition of angiotensin II binding to AT1 inhibits its AT1-mediated vasoconstrictive and aldosterone-secreting effects and results in decreased vascular resistance and blood pressure.

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Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.

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The efficacy of telmisartan in the treatment of hypertension has been demonstrated in placebo-controlled trials.

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