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Impact of Erythropoiesis-Stimulating Agents on Energy and Physical Function in Nondialysis CKD Patients With Anemia: A Systematic Review.
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High Dose Epoetin Beta in the First Weeks Following Renal Transplantation and Delayed Graft Function: Results of the Neo-PDGF Study.
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Relationship Between Changes in Hemoglobin Level and Quality of Life During Chemotherapy in Anemic Cancer Patients Receiving Erythropoietin Therapy, they concluded that there was a direct relationship between the hemoglobin increases during Epoetin alfa therapy and corresponding quality of life improvements in cancer patients receiving chemotherapy across the clinically-relevant range of 8-14 grams per deciliter.
The trial enrolled 4038 patients; 2012 received darbepoetin alfa, and 2026 received placebo.
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TIW achieved a hematocrit of 38% without administration of transfusions or significant reduction in zidovudine dose.
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This recombinant erythropoietin, a 165-amino acid glycoprotein (about 62% protein and 38% carbohydrate), regulates red blood cell production.
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Failure of one therapeutic regimen often precludes success with others because of the high degree of cross-resistance among antiretroviral drugs.
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The anemia of CKD is typically normochromic and normocytic and is caused primarily by a decrease in erythropoietin production relative to the degree of anemia.
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If multiple Hb values were drawn within the 6-month time period, the Hb value closest in time to the D25 level was used.
The number of erythroid precursor BFU-E in bone marrow and peripheral blood increased significantly during the course of therapy, confirming the stimulatory effect of recombinant erythropoietin on the earliest stages of erythropoiesis.
The experience of biopharmaceuticals suggests that seven processes and practices are required for proficiency in personalized medicine.
This results in an increase in reticulocyte counts followed by a rise in hematocrit and hemoglobin levels.
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Downregulation of cell survival signalling pathways and increased cell damage in hydrogen peroxide-treated human renal proximal tubular cells by alpha-erythropoietin.
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The drug is used when the body is unable to produce enough human erythropoietin.
Although donated human plasma is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease.
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Erythropoietin has an anti-myeloma effect - a hypothesis based on a clinical observation supported by animal studies.
Erythropoietin response to anaemia is not altered by surgery or recombinant human erythropoietin therapy.
Prevalence and predictors of epoetin hyporesponsiveness in chronic kidney disease patients.
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